The HFpEF Obesity Phenotype
نویسندگان
چکیده
منابع مشابه
Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype.
OBJECTIVE In previous studies of associations of variants in the genes UCP2, UCP3, PPARG2, CART, GRL, MC4R, MKKS, SHP, GHRL, and MCHR1 with obesity, we have used a case-control approach with cases defined by a threshold for BMI. In the present study, we assess the association of seven abdominal, peripheral, and overall obesity phenotypes, which were analyzed quantitatively, and thirteen candida...
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Asthma is a disease with distinct phenotypes that have implications for both prognosis and therapy. Epidemiologic studies have demonstrated an association between asthma and obesity. Further studies have shown that obese asthmatics have poor asthma control and more severe asthma. This obese-asthma group may represent a unique phenotype. The mechanisms behind poor asthma control in obese subject...
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Background Heart failure with preserved ejection fraction (HFPEF) carries significant mortality and morbidity. This population is characterized by marked heterogeneity. To date, this population has been poorly phenotyped and it remains unclear what proportion may have evidence of myocardial infarction (MI), undiagnosed cardiomyopathies or phenocopies of heart failure. At present, echocardiograp...
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Heart failure with preserved ejection fraction (HFPEF), a clinical syndrome where heart failure (HF) exists in the presence of normal or near-normal left ventricular ejection fraction (LVEF), accounts for up to half of all HF patients. However, in contrast to heart failure with reduced ejection fraction (HFREF), where therapeutic advances have significantly improved outcomes over the last two d...
متن کاملHFpEF, diastolic suction, and exercise.
a d m t p d m o t s Heart failure with preserved ejection fraction (HFpEF) is a disease of the myocardium, the vascular tree, the pulmonary circulation, and the kidneys. It may to some extent be attributed to unsuccessful aging. Why is a patient with HFpEF short of breath when exercising? In order to differentiate between a cardiac and a pulmonary etiology, Borlaug et al. (1) subjected patients...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2016
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2016.05.019